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There is no question as to why bodybuilders of the modern era utilize human growth hormone. Its ability to regulate fat loss, pack on size and increase levels is just a few of the many attributes that many seek. HGH Frag 171-191 was developed so that bodybuilders and athletes not looking for the growth properties from HGH could still reap all the results of its amazing fat loss properties.
HGH FRAG in Action
As a part of a peptide regiment, bodybuilders should seriously consider adding HGH Frag into their protocols. It has an incredibly ability to regulate fat metabolism without the adverse side effects on insulin sensitivity. By isolating the tail end of the GH molecule, scientist have found that HGH Frag 176-191 works even better than HGH to stimulate lipolysis (breaking down of fat). In fact, it actually inhibits lipogenesis; meaning, it stops formation of fatty acids and other lipids. Also, unlike other fat burning compounds out there, users will not experience hunger suppressing qualities or the jittery feelings that can be associated with ephedrine like compounds (think ). Since it does not compete for HGH receptors, multiple studies have shown that HGH Frag 176-191 will not cause hyperglycemia. In addition, it will promote lean body mass, protein synthesis, increase bone mineral density, and better sleep.
Dosage and Usage
HGH Frag is like all of the other we have covered and come as a delicate lyophilized powder that should be kept out of the light and in a cool dry place. Reconstitution is done with bacteriostatic water or sodium chloride meant for injection. In order to reap the benefits of HGH Frag, users will need to dose around 500mcgs per day. This can be done by dosing 250mcgs in the morning pre-workout, and 250mcgs before lunch or 250mcgs before bed. Users will also want to take note of the timing of injections and their diet at that time. It is optimal to inject HGH Frag 176-191 on an empty stomach or with just protein in the stomach. Like other peptides, HGH Frag has been noted to not work as effectively in the presence of carbohydrates and sugars.
The side effects most commonly associated with HGH Frag 176-191 are few but can include: redness or soreness at the site of injection, and excessive sleepiness or lethargic feeling. Other than that, the positive side effects are many. HGH Frag 176-191 destroys fat, promotes lean body mass, does not affect glucose levels, helps to strengthen bones, can improve sleep patterns for many and helps protein synthesis.
For the cost and the ability to totally break down fat, HGH Fragment is an amazing tool to use along with your favorite GHRH and GHRP peptide protocol. The added benefits, without any of the nasty unwanted side effects associated with exogenous growth hormone, make HGH Frag 176-191 extremely attractive. No more worrying about thyroid issues, glucose sensitivity, tingling, or carpal tunnel problems. Just the ability lean out and increase vascularity while still being able to slab on lean body muscle.
What is IGF1-LR3
IGF-1 is basically a polypeptide hormone that has the same some of the same molecular properties as insulin. IGF dose actually stand for insulin-like growth factor. IGF-1 is mainly responsible for long bone growth in children and it also affects muscle growth and repair of adults. Long R3 IGF-1 is a more potent version of IGF-1. It's chemically altered i like to think "enhanced" to prevent deactivation by IGF-1 binding proteins in the bloodstream. This results in a longer half-life of 20-30 hours instead of 20 min... So that means a far more effective version than the short chain we we re perhaps more familiar with.
IGF1-LR3 What does it do?
IGF-1 LR3 greatly boosts muscle mass by inducing a state of muscle hyperplasia (increase in number of new muscle cells) in the MUSCLE WHERE ITS INJECTED! So think of it as muscle cell proliferation, or even the splitting of the cell so 1 becomes 2... That's why its perfect on cycle when you get increased muscle cell growth too. But why is IGF better than ? The reason being is HGH causes IGF levels to rise in the liver first, then then the muscle, Whereas IGF-LR3 causes localized IGF levels to rocket.
Igf1-lr3 As you all know is the long acting version of Igf-1, Taking its active potential up towards 20 hours, But along with its ability to stimulate the growth of satellite muscle cells and helping them to mature into new muscle fibers it holds the ability to increase the uptake of many supplements we currently use, And it can cause the enhanced recovery of testicle size, and prevent muscle loss even in PCT. Plus another reason its so potent is because of the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF.. not so with this long acting version.
Firstly, to clarify this peptide, GHRP-6 is a peptide a Growth Hormone Releasing hexapeptide, it's a 28 amino acid peptide, and it works by signaling to the pituitary gland to begin secreting Growth Hormone.
Molecular Formula: C46H56N12O6
Molecular Weight: 873.01
CAS Registry Number: 87616
GHRP-6 lacks opioid activity, but you get a huge pulse, (dose dependent) in your own GH levels, and you get the effects of the increased IGF-1 secreted by the liver. Now both the increased GH and are highly desirable for athletes, bodybuilders and those looking to improve their own physique.
Now, you may have heard many bodybuilders saying that when you take GHRP-6 that they get a huge and very intense increase in appetite, about 20 mins after the initial injection. Well, this is caused by the GHRP-6 antagonising the peptide Ghrelin, it mimics it, but, in reality, it actually fights against it causing the signal for gastric emptying and hunger. Ghrelin is what many believes causes obesity, and insulin resistance amongst other things, and I believe this is one way by which GHRP-6 may help reduce fat, by fighting against it. However, there is always a but, if you take more than 150mcg the effects of the gastric emptying can be so strong that you may have the urge to severely stuff yourself with food, so if you're on a bulking cycle this is a great side effect, and, considering the price, it's a very cost-effective one. Therefore, during a bulking run, I rate this as the number one aid in increasing appetite, as you also get very a good anabolic effect and increased strength.
In one study, it was shown that GHRP-6 has a protective effect on the liver that seems to be mediated by IGF-I, TNF-alpha, and nitric oxide. Data also suggest that the anti-inflammatory effect of GHRP-6 in the liver is exerted on nonparenchymal cells, so, again, for pct this may prove an invaluable asset.
As for peptides, in general, they are fairly new as compared to other anabolics, but they are far better, and have way more potential during cycles and PCT, just how much remains to be seen.
Just remember not to eat carbs or fats 50 mins before and after a dose of GHRP-6 so as not to interfere with the pulse it will cause. In addition, 250mcg 3 times a day is the best dose I found to avoid overly mimicking ghrelin and still cause a large amount of muscle gain, tissue repair and fat loss.
As a peptide GHRP-6 is one of the easiest and most affective to use. A daily dose of just 300mcg split up into 3 doses will see a marked improvement in
GHRH’s are paired specifically with GHRP’s in order to create a synergy between the peptides that will unlock the body’s own stores of growth hormone. Even though many peptides work in some capacity by themselves, it is most beneficial to run your GHRH alongside a GHRP. This is why CJC 1295 is highly desirable, and it's one of the most widely used in the community. Right now, it has been debated which CJC 1295 is best to use. While MOD GRF (CJC 1295 no DAC) is commonly used with GHRP’s to increase pituitary GH pulse, more frequent injections will need to be administered. The CJC 1295 with DAC will result in a series of smaller pulses; therefore, injections will be less frequent - often two to three times a week.
DAC or no DAC?
As just stated above, when a person sees the term CJC 1295 without DAC this is really means that they are looking at MOD GRF 1-29. This peptide is a modified version of the original GRF 1-29 peptide better known as Semorelin. Due to the extreme short half life of the original GRF 1-29, chemists were able to modify the peptide to offer a longer biological activity that reduced the metabolic clearance. Although with MOD GRF 1-29 its modification had resulted in a greater peptide bond, the average user will still likely need to inject two to three times a day with a GHRP to get the maximum effectiveness for releasing endogenous growth hormone. Now when the drug affinity complex (DAC) was added to CJC 1295, it allowed for an even greater possibility to utilize smaller pulses (what was once thought of as a bleed) that, when combined with a GHRP, will activate growth hormone stores to release throughout the day and night. When the DAC component was added, this allowed the peptide half-life to be extended to about one week and also provided for steadier blood levels after injection. Now that we understand how important the DAC factor is, this becomes a much more viable and cost effective way to utilize CJC 1295 with DAC along with a GHRP. The DAC, when added, is able to bind to albumin that circulates the body, literally being able to last for days as it looks for receptors to bind to. So, in short, if you prefer to use shorter spikes of GH release then the use of the MOD GRF 1-29 (CJC 1295 without DAC) is going to be optimal. However, if your prefer fewer injections and still want to unleash your growth hormone stores, then 2-3 times a week injections of CJC 1295 with DAC along with your daily injection of GHRP would be the way to proceed for maximizing growth hormone release.
Dosage and Usage
The naming might have thrown you for a loop, but don’t let that stop you from understanding the reason why you should utilize one of the best GHRH’s out there. CJC 1295 is probably the best and most widely use GHRH along with your chosen GHRP. Like all of the other peptides you are dealing with, it is a delicate lyophilized powder that should be kept out of the light and in a cool dry place. Reconstitution is done with bacteriostatic water or sodium chloride meant for injection. As already stated before, to mimic the natural release of growth hormone through the natural spikes you would achieve through the day MOD GRF 1-29 (CJC 1295 without DAC) should be injected 1-3 times per day at 100mcg-200mcg doses along with your GHRP of choice. Now, the most cost effective and in my opinion better way to utilize CJC 1295 is to go with the CJC 1295 with DAC. This will allow the bodybuilder or athlete to inject 2mg of CJC 1295 with DAC twice weekly along with their daily injection of GHRP. This will offer smaller but more frequent growth hormone pulses that would ideally get a user closer to exogenous HGH doses.
Water retention, tingling, numbness and decreased insulin can be associated with use of CJC 1295. Also noted is tiredness, feeling of lethargy, head rush or euphoria, itching. Positive side effects can be increased lean body mass, increased protein synthesis, faster recover, reduced body fat, promotion of bone density, and cellular stimulation for internal organs and skin cells.
In conclusion, CJC 1295 with DAC is a powerful growth hormone releasing hormone that can be effectively used with a GHRP in order to maximize the greatest endogenous growth hormone release bodybuilders and athletes are looking for. Even though CJC 1295 with DAC may be a bit more expensive than MOD GRF 1-29 (CJC 1295 without DAC), it is still the preferred and more powerful GHRH component in your peptide protocol.
Growth hormone has many systematic effects, from improved strength, anti-aging effects on skin, tendon strengthening, increased IGF levels, better sleep, to name just a few.. but when Synthetic GH is taken.. most of these effects are minimized, as synthetic GH doesn't imitate the cascade of GH that subjects pituitary creates, and the effects it has…
So what if you could harness say one aspect of GH specifically lets say.. The profound effect it has on fat loss, and produce a peptide that imitates GH in that regard. Introducing HGH Fragment
Hgh fragment 177-191is a stabilized analogue of the growth hormone-releasing factor (GRF) that induces Growth Hormone in a specific and physiological manner. To date, studies suggest that HGH Fragment 177-191 has several beneficial features: it reduces abdominal fat in particular visceral fat, without compromising glycemic control (blood glucose), it increases muscle mass and improves the lipid profile, so it looks to have a lot of key benefits.. but does it?
Studies that can be found easily show that at a dosage of 500mcg, HGH Fragment 177-191 was shown to increase lipolytic activity in adipose tissue ,this HGH Fragment potently burns body fat, especially stubborn adipose body fat, and at the same time as it doesn't spike glucose levels, or cause any problems with insulin sensitivity, and improving your lipid profile, this really should be part of any dedicated athletes fat loss regime.
Unlike GH, HGH fragment doesn't induce cell proliferation, it does not induce hyperglycemia or reduce insulin secretion. HGH fragment 177-191 does not compete for the hgh receptor, but of important note.. is the HGH Fragment’s ability to increase IGF-1 levels which translate into the HGH Fragment’s ability to give collateral anti-aging and anabolic effects along with its ability to induce fat loss in the most stubborn body fat (adipose tissue) while increasing energy expenditure and glucose and fat oxidation.
The good news is, the subjects body is burning fat for fuel and energy!! And add to that a whole host of health benefits and everything looks great, However it does seem to cause the thyroid to become sluggish, not as potent as GH, but perhaps through its ability to increase cortisol it still slows the thyroid..
So we suggest that HGH fragment should be stacked.
CJC-1295, also known as DAC:GRF (short for drug affinity complex:growth hormone-releasing factor), is a of (GHRH) (also known as growth hormone-releasing factor (GRF)) and a (GHS) which was developed by . It is a modified form of with improved , especially in regard to .
CJC-1295 markedly increases (GH) and (IGF-1) levels in both animals and humans. With a single injection, in human subjects, CJC-1295 increases plasma GH levels by 2- to 10-fold for 6 days or longer and plasma IGF-1 levels by 1.5- to 3-fold for 9 to 11 days. The drug has an estimated of about 6 to 8 days in humans. With multiple doses of CJC-1295, IGF-1 levels were found to remain elevated in humans for up to 28 days.
CJC-1295 has been shown to extend the half-life and bioavailability of 1-29 and stimulate secretion. It increases the half-life of acting agents by .
CJC-1295 was under investigation for the treatment of and and reached but was discontinued upon the death of one of the trial subjects. The attending physician of the trial believed that the most likely explanation for the incident was that the patient had asymptomatic with plaque rupture and occlusion, and that the occurrence was unrelated to treatment with CJC-1295. In any case, research was terminated nonetheless as a precaution. CJC-1295 has found use for purposes, with this, in some countries such as the , being an .
Unlike GHRP-6 , GHRP-2 does not come with the heavy hunger side effect, but still maintains all the benefits of activating ghrelin. You may be contemplating why is ghrelin so important for a growth hormone releasing peptide? Let’s take a closer look.
The Ghrelin antagonist named GHRP-2
Ghrelin is a regulatory GH secretion that is produced inside the stomach and is largely regulated by a person’s nutritional intake. that ghrelin increases during times of fasting and anticipation of meals. This is the main reason why the users of GHRP-6 will experience extreme hunger as the peptide mimics the affects of ghrelin acting as if the stomach is in a state of fasting. GHRP-2 does the same, but chemists were able to dial back the severity of the hunger sides with GHRP-2. This is not to say that GHRP-2 will not increase hunger in most users, as it most definitely will, as you can see represented in the table below:
How does it Work?
The single polypeptide chain composed of six amino acids is a growth hormone releasing peptide. This hexapeptide not only functions to stimulate ghrelin release, but it also works to correct production of low level growth hormone. Simply put, GHRP-2 is perfectly designed with the intention of releasing human growth hormone from the pituitary gland. These mechanisms have been shown to promote lean body gains in lean body individuals. Since GHRP-2 is a ghrelin agonist, it helps to promote the secretion of human growth hormone in a two fold process. For one, it acts to boost growth hormone through amplification of the transduction pathway. In addition, it suppresses the action of somatostatin (a hormone which limits the release of growth hormone). These actions make GHRP-2 a perfect option to increase endogenous growth hormone levels.
Dosage and Usage
Just like the other peptides we have covered so far, GHRP-2 comes as a lyophilized powder. It must be stored in a cool dry place and should be reconstituted using bacteriostatic water or sodium chloride meant for injection. Once the peptide has been reconstituted, GHRP-2 must be kept in a cold storage like the refrigerator until ready for use. GHRP-2 can be taken in high dosages, if needed; however, it is still unclear how effective these high doses are. Normally, GHRP-2 will be used 2-3 times a day at around 100mcg-300mcg per injection. As with other GHRP’s, it's highly advisable to also use a GHRH in order maximize the effectiveness of the pulse wave combination in accessing the pituitary pathway to release growth hormone.
As already stated, the hunger side effects tied to GHRP-2 should be duly noted. Usage of this peptide can also come with elevated levels of cortisol and prolactin, especially if users are dosing in the higher ranges – over 200mcg/injection. Another common side effect is the feeling of lethargy and tiredness upon first using GHRP-2. Water retention, tingling, numbness and decreased insulin sensitivity have also been cataloged as effects of GHRP-2. The most common positive side effect that bodybuilders and athletes will find with GHRP-2 are: decreased body fat, increase lean body mass, improved sleep, increase in IGF-1 production, increase in bone density and increase in cellular repair. While GHRP-2 has good and bad side effects, it should also be taken into consideration that compared to or GHRP-6, GHRP-2 is actually the mildest GHRP next in line to Ipamorelin.
If you are looking for anti-aging properties or for the ability to increase lean body mass gains on cycle/off cycle, or even as a bridge, GHRP-2 will help you on that path. It is a very potent growth hormone releasing peptide. As always, please be advised that while it does come with some side effects, GHRP-2 will not shut down your natural production of growth hormone like exogenous will. With a proper diet and training, users can utilize GHRP-2 along with a GHRH as a tool that is safe and effective for athletes and bodybuilders alike.
For starters Hexarelin is not your average GHRP. The structure of the amino acid is that of a hexapeptide known to help promote the release of growth hormone (GH). The mechanism of action is not yet fully understood by scientists. However, what we know is that hexarelin has the ability to act both on the pituitary gland and the hypothalamus. It is known to give the largest release of GH than any other GHRP.
Like other peptides, hexarelin has the ability to help promote more production of natural growth hormone, and it will not shut down the production of the body’s ability to produce GH. Hexarelin has been shown in to increase bone mineral density, mitosis and meiosis, fat loss, connective tissue strengthening, and improved skin elasticity.
What were the benefits of Hexarelin?
What are the side effects?
Interestingly, the most amazing finding with hexarelin was its ability to act on cardiac receptors separate from the GH releasing properties. The peptide can directly aid in cardio protective left ventricular pressure issues, as well as, help healing scar tissue on the heart. Studies on lean and obese lab rats concluded that while lean rats were able to take advantage of the GH plasma increase better than the obese rats (the healthier the rat the more hexarelin effectively produced and utilized GH), obese rats did not see the same advantage. Separate from the studies that monitored GH, both lean and obese rats both received all of the cardio protective properties of hexarelin.
How does it Work?
When Hexarelin is given as a subcutaneous injection, it activates the pituitary via a pulse, just like GHRP-6, and helps circulate growth hormone in the body. Unlike , it does not induce any hunger side effects. Hexarelin has the ability to not only raise the level of GH in the body but to also suppress somatostatin, which is the main culprit that inhibits GH from being released. This means that there will be more GH in abundance. In addition, hexarelin is the strongest GHRP available, so users should notice that desensitization can come much quicker than other GHRP’s. This makes it less ideal for long term use, but with hexarelin’s ability to raise healthy levels of IGF-1 and GH it can work perfect as a PCT tool for those coming off a synthetic GH/IGF-1 cycle. The potency of this peptide should not be underestimated and it comes with an increase in cortisol production as well as prolactin. Nothing close to what might be seen in elevated levels from , but compared to other GHRP’s it has the strongest affinity to raise cortisol/prolactin.
Dosage and Usage
Hexarelin comes in a freeze dried powder just like the other GHRP peptides and storage should be done in a cool dry place until reconstituted and placed in a refrigerator. Bacteriostatic water is used to reconstitute the powder and an insulin syringe is the preferred method for administering subcutaneous injections of hexarelin. Users will notice 200mcgs is the saturation dose for hexarelin and over a few weeks of use total desensitization may begin to take place. Also, the occasional flare up of the pituitary has been noted when dosing far beyond saturation doses. Desensitization can be cleared easily by taking a break from hexerlin usage for a few days to a few weeks. This GHRP is the strongest, and because of the desensitization factor, I believe the optimal way to use this peptide would be to blend it at low doses with other GHRP’s like GHRP2, GHRP6 or iPamorelin. By combining a low dose of hexearelin with another GHRP, you are going to increase your ability to put out a greater pulse of growth hormone. Combine this with GHRH’s and you have a synergistic blend that will release GH more effectively. In fact, for synthetic users, this may be a viable way to save money on using less exogenous GH by combining it with hexarelin in a GHRP+GHRH cycle. As a result, utilizing hexarelin in this protocol would establish the maximum GH release in the body.
Jintropin is a supplement containing human growth hormone that many athletes take in hopes of enhancing strength, agility and exercise performance. Other people take Jintropin believing it can turn back the clock and forestall the aging process. However, with clinical results mixed and many potential side effects as well as legal considerations, supplements like Jintropin are generally only recommended for a few special medical conditions. Exercise caution if considering using this supplement.
Jintropin claims bodybuilders prefer the product over anabolic steroids due to its ability to promote clean muscle growth without the harmful side effects of growth from steroids. The company also claims Jintropin can reduce excess body fat, particularly abdominal fat, reduce skin wrinkles and other visible effects of aging, increase bone density, strengthen the immune system and re-grow internal organs that have atrophied with age.
Growth hormone has been studied in various animal and human clinical trials, but MayoClinic.com notes there has been little in the way of results to show that HGH can help otherwise healthy adults regain their youth and vitality. However, HGH does have benefits if you have a true growth hormone deficiency unrelated to aging. This condition is rare, often caused by a pituitary tumor, and HGH helps to increase bone density, muscle mass and exercise capacity while decreasing body fat in these patients. Humane growth hormone is also approved for the treatment of muscle wasting in patients with HIV or AIDS.
A study published in “Neuroscience” in 2004 on HGH in laboratory animals over a period of four months found that the supplement helped improve age-related learning impairment and cognitive decline. Human growth hormone injections have been shown to increase muscle mass and reduce body fat in older adults, and in fact, HGH treatments like Jintropin may show more results in older adults than in younger adults. Adult studies have not been long term, however, so it remains to be seen if the benefits will last or if there are additional benefits, as well as whether the side effects involved will disappear or become even worse.
If you are a healthy adult taking Jintropin or another human growth hormone product, you may experience carpal tunnel syndrome, swelling in your arms and legs, joint and muscle pain or enlargement of breast tissue in men, called gynecomastia. HGH may also be a contributing factor to the development of diabetes and heart disease. Human growth hormone can lead to a condition known as acromegaly, abnormal growth of the hands and feet. HGH use in children has also been associated with a higher risk of cancer in later years.
Melanotan II was first developed by a group at the University of Arizona with the intent of creating a peptide that could lower the risk for skin cancer. They succeeded and found that they could increase the amount of melanin naturally with M2, which helps protect skin and organs from ultra violate rays. As an added benefit, they found that it also increased libido in males who did not respond well to Viagra. have shown that Melanotan II could be used as a replacement therapy for patients with inadequate response to PDE5 inhibitors. Also noted was the ability for it cause weight loss as well as decrease appetite.
Why Melanotan II
For a bodybuilder planning to compete on stage, there is a considerable amount of time and attention to detail committed before they are ready to compete. Being muscled up and defined is only accentuated by a nice tan to make lines and definitions pop out and become more evident to viewers and judges. Enter the heptapeptide Melanotan II, now bodybuilders can actually protect themselves from over exposure to the sun while boosting melanin. This results in a darker and more tanned complexion. When Melanotan II is added to a peptide protocol leading up to a show, it will boost melanin levels, resulting in tanner skin; in addition, it will increase fat loss and muscle hardness.
Dosages and Usage
Like every we have discussed thus far, please remember that peptides come in the form of a white delicate powder and should be stored out of light in a cool dry place. All peptides need to be reconstituted with bacteriostatic water or sodium chloride specifically used for injections. In order to use Melanotan II effectively, you need to understand your skin type. To keep things simple, we can go ahead and break skin types into three categories.
Beyond that, if your pigmentation is already naturally olive or darker, you will need to use less Meanotan II for your tanning needs. The tan results coupled with exposure to sunlight and UV rays should last a user all summer or through a season.
Daily Dosages vary depending on your needs:
Taking too much M2 can make you somewhat yellowish, so you need to start slowly with lower doses and move your way up.
The side effects associated with Melanotan II are similar to other peptides: flushed face, headache, feeling dizzy, lethargy, nausea, white patches and possible soreness or redness at site of injection. The benefits users get from Melanotan II are: darker skin pigmentation, appetite suppression, fat loss, lean body mass, increased libido and frequency of erections.
There is a serious anecdotal note about Melanotan II, some users have experienced serious nausea after using M2. This is variable from user to user, but has to be a concern. You need to feel out your dosages and start slow before you go head long into using this peptide.
In bodybuilding, especially at the competitive level, everything is taken into consideration even the darkness of your tan. Therefore, it's best you use a peptide like M2 for tanning instead of going to the tanning bed every day. Remember guy, tanning beds cause cancer!
If you don’t compete, but still want to maintain an even tan this upcoming spring/summer, then Melnaotan II is the best peptide to work into your protocol. Its added effects of sexual arousal and fat loss are welcome benefits for users who want to have that summer beach body. After all, what good is a buff tanned body if you can't get it up.