Cock Bombs 70mg — Dual PDE5 Inhibitor Combination by Dragon Pharma
Cock Bombs is Dragon Pharma's combination formula delivering both Sildenafil and Tadalafil in a single 70mg tablet — the two most clinically established PDE5 inhibitors combined to address their individual pharmacokinetic limitations: Sildenafil provides rapid onset (30-60 minutes) with a 4-6 hour window; Tadalafil provides extended duration (24-36 hours) that begins acting as Sildenafil's shorter window closes. The result is dual-phase PDE5 coverage — immediate erectile support from the Sildenafil component and sustained PDE5 inhibition through the following day from the Tadalafil component — from a single pre-activity dose.
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The Pharmacokinetic Rationale — Why Combining Both PDE5 Inhibitors Makes Sense
The combination is not arbitrary — it addresses a genuine complementary gap in the single-compound profiles:
- Sildenafil alone: Onset in 30-60 minutes; peak at 60-90 minutes; effective for 4-6 hours then blood levels drop below therapeutic threshold. Takes effect quickly but requires timing precision — must be taken close to anticipated activity. High-fat meals significantly delay absorption
- Tadalafil alone: Onset also 30-60 minutes but reaches full therapeutic blood levels more gradually than Sildenafil's sharper peak. Duration 24-36 hours — enables spontaneous activity throughout the following day but the initial effect onset can feel less immediate than Sildenafil's faster peak
- The combination rationale: Sildenafil's sharp concentration peak provides the immediate, noticeable onset that users associate with rapid effect. Tadalafil's gradual but very long-lasting profile then takes over as Sildenafil's shorter-acting component clears — maintaining PDE5 inhibition through the following 24+ hours. One dose provides both the "now" effect and the "tomorrow" coverage
- The two compounds work through identical PDE5 inhibition of the cGMP/smooth muscle relaxation cascade in the corpus cavernosum — their combination is pharmacodynamically additive at the PDE5 level rather than synergistic through different pathways. This means combined hypotensive effects are also additive — both cardiovascular and blood pressure considerations apply to the combined dose
The Complete PDE5 Inhibitor Comparison
| Parameter | Cock Bombs (50mg S + 20mg T) | Sildenafil 50mg | Tadalafil 20mg | Vardenafil (Levitra) |
|---|---|---|---|---|
| Onset | 30–60 min | 30–60 min | 30–60 min | 15–30 min |
| Peak effect | Sildenafil peak at ~60-90 min | ~60–90 min | ~120 min | ~45–60 min |
| Duration | 4–6h (S) then 24–36h (T) | 4–6 hours | 24–36 hours | 4–6 hours |
| Food interaction | Take after light meal or fasted | Avoid high-fat meals | No restriction | Avoid high-fat meals |
| Hypotension risk | Higher — two compounds combined | Standard | Standard | Standard |
| Best for | Maximum coverage; planned + spontaneous | Planned timing | Spontaneous; daily | Fastest onset |
PDE Selectivity — Why Both Compounds Together Still Targets PDE5
An often missed consideration about the combination:
- Both Sildenafil and Tadalafil are PDE5-selective inhibitors — they primarily inhibit PDE5 in the corpus cavernosum to produce erectile effects. However, their selectivity profiles for other PDE subtypes differ slightly
- Sildenafil also inhibits PDE6 (present in retinal photoreceptors) at higher doses — producing the blue-tinge visual effect some users notice at 100mg. At 50mg this is less pronounced
- Tadalafil has some activity at PDE11 (present in testicular tissue and cardiac muscle) — the clinical significance for testicular function in AAS users is not fully established but is a consideration for long-term daily Tadalafil use
- In the combination tablet, the 50mg Sildenafil provides the primary fast-onset PDE5 hit while the 20mg Tadalafil (a lower dose than its maximum 20mg standalone) carries the duration — combining standard clinical doses of both compounds
AAS-Context Application
The combination tablet's dual-phase profile has specific relevance for AAS users:
- On-cycle ED often fluctuates — estrogen elevation, prolactin effects, and androgenic changes can produce unpredictable erectile function. The Tadalafil component's 24-36 hour coverage means one evening dose maintains PDE5 inhibition through the following day without needing to time a second dose
- Post-cycle ED during recovery phase similarly benefits from sustained coverage — the combination provides both the acute effectiveness needed immediately and the sustained background coverage through recovery periods where hormonal fluctuation is ongoing
- Sildenafil's food sensitivity remains relevant for the combination — take on a light stomach or fasted for fastest onset from the Sildenafil component
Effects and Benefits
- Rapid onset from Sildenafil component — 30-60 minutes to noticeable effect
- Extended duration from Tadalafil component — 24-36 hours of continued PDE5 inhibition after the Sildenafil window closes
- Single-dose dual coverage — no need to choose between immediate and sustained effect
- Full clinical dose of both components — 50mg Sildenafil and 20mg Tadalafil are standard therapeutic doses for each compound
Dosage and Administration
| Dose | Timing | Notes |
|---|---|---|
| ½ tablet (35mg) | 30–60 min before activity | Starting dose for PDE5 inhibitor-naive users; assess response |
| 1 tablet (70mg) | 30–60 min before activity | Standard dose for most users; Sildenafil component benefits from light stomach |
Maximum one tablet per 24 hours — the Tadalafil component's long half-life means the second dose would be additive on still-active Tadalafil blood levels from the previous dose, increasing hypotensive risk. New PDE5 inhibitor users should begin with half a tablet.
Side Effects
- Hypotension — the primary concern with the combination; additive vasodilation from both compounds; more pronounced than single-agent use
- Headache and flushing — vasodilation effects; common with either agent alone, potentially more pronounced with combined use
- Visual disturbances — from Sildenafil's PDE6 activity; blue/green tinge at higher doses; less likely at the 50mg Sildenafil dose in this combination
- Nasal congestion — vasodilation in nasal mucosa
- Back/muscle ache — from Tadalafil component specifically; known Tadalafil side effect
Related Products
- Sildenafil Viagra DP — standalone 50mg Sildenafil for planned activity with specific timing; no Tadalafil duration component
- Cialis DP (Tadalafil) — standalone Tadalafil; ideal for daily low-dose protocol (2.5-5mg/day) or single-dose spontaneous activity without Sildenafil onset speed
- Levitra (Vardenafil) — standalone Vardenafil; fastest onset of the three single-agent PDE5 inhibitors; for users wanting maximum onset speed without combined formulation
"Cock Bombs combines Sildenafil's 30-60 minute onset peak with Tadalafil's 24-36 hour sustained coverage in one tablet — the pharmacokinetic logic is that Sildenafil delivers the immediate effect while Tadalafil maintains PDE5 inhibition through the following day, eliminating the timing precision required when using either compound alone."
Storage and Handling
Store at room temperature, away from direct sunlight and moisture. Keep in original packaging until use.
