Dragon Pharma — Post Cycle Therapy
6 PCT products covering the complete HPG axis recovery protocol — SERMs for pituitary LH/FSH stimulation, HCG for Leydig cell maintenance and reactivation, HMG for FSH-driven spermatogenesis, and Enclomiphene as the cleaner selective estrogen receptor modulator alternative.
Post Cycle Therapy (PCT)
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Dragon Pharma PCT — HPG Axis Recovery Protocol
All AAS suppress the HPG (Hypothalamic-Pituitary-Gonadal) axis through androgen receptor-mediated negative feedback — LH and FSH production falls, Leydig cells stop producing testosterone, and natural testosterone reaches suppressed levels during the cycle. Post Cycle Therapy is the structured pharmacological approach to restoring this axis after AAS use. Dragon Pharma's 6-product PCT range addresses every level of the recovery cascade — from hypothalamic and pituitary SERM intervention through direct Leydig cell stimulation with HCG to FSH-driven spermatogenesis restoration with HMG.
SERMs — The HPG Axis Restart Foundation
Selective Estrogen Receptor Modulators are the cornerstone of every PCT protocol. By blocking estrogen receptors at the hypothalamus and pituitary, SERMs remove the estrogen negative feedback signal that suppresses GnRH, LH and FSH production — allowing the axis to resume natural hormone output. Clomid (Clomiphene Citrate) is the most established PCT SERM — mixed isomers (active enclomiphene + estrogenic zuclomiphene), strong LH and FSH stimulation. Nolvadex (Tamoxifen Citrate) — first-generation SERM whose primary activity is through its active metabolite Endoxifen (100× more potent than parent); ERα antagonism at breast tissue and HPG axis with bone density preservation. Both are commonly combined at lower individual doses for heavier cycle recovery.
Enclomiphene — The Cleaner SERM Alternative
Enclomiphene is the trans-isomer of clomiphene — the pharmacologically active component of Clomid separated from zuclomiphene (the partially estrogenic cis-isomer that contributes to Clomid's mood and vision side effects). Pure enclomiphene produces LH and FSH stimulation equivalent to or greater than mixed-isomer Clomid with a significantly cleaner side effect profile — fewer mood disturbances, no estrogenic activity from the zuclomiphene component. For users who have experienced Clomid side effects or prefer a more selective SERM, Enclomiphene is the direct improvement.
HCG — Leydig Cell Maintenance and Reactivation
Human Chorionic Gonadotropin is an LH mimetic — it binds LH receptors on Leydig cells and directly stimulates testosterone production, independently of pituitary LH output. During AAS cycles, LH suppression causes Leydig cell atrophy — cells reduce in size and steroidogenic gene expression falls. HCG maintains Leydig cell function throughout suppressive cycles, ensuring PCT begins with responsive testes rather than atrophied cells that respond poorly to restored LH. Two vial sizes: HCG 5000IU for longer cycles and pre-PCT blast protocols (250-500IU every 3-4 days during cycle; 1,000-2,000IU daily for 5-10 days pre-PCT); HCG 2500IU for shorter cycles and single blast protocols.
HMG — FSH Component for Spermatogenesis
HMG 150IU (Menotropin) contains both LH and FSH (75IU each) — adding the FSH component that HCG alone does not provide. FSH drives Sertoli cells in the testes which support spermatogenesis; without FSH, sperm production cannot be fully restored regardless of LH-driven testosterone recovery. For users prioritising fertility and spermatogenesis restoration alongside testosterone recovery, HMG alongside or instead of HCG provides the complete gonadotropin signal.
PCT Timing — When to Start
PCT timing depends entirely on the ester half-life of the last AAS injected. The principle: PCT SERMs should begin only after exogenous AAS has substantially cleared — starting while active suppressive compound is still circulating makes SERM intervention counterproductive. Guidelines: Short esters (Propionate, Acetate, Suspension) — begin PCT 3-5 days after last injection. Long esters (Enanthate, Cypionate, Decanoate) — begin PCT 2-3 weeks after last injection. Undecanoate — begin PCT 4-6 weeks after last injection. HCG pre-PCT blast (if used): 1,000-2,000IU daily for 5-10 days immediately before SERM PCT begins, then stop HCG and start SERMs.
Frequently Asked Questions
The most commonly used PCT after a standard testosterone Enanthate or Cypionate cycle: begin PCT 2-3 weeks after last injection. Clomid 50mg/day weeks 1-2, 25mg/day weeks 3-4. Nolvadex 40mg/day weeks 1-2, 20mg/day weeks 3-4. Both can be combined at reduced individual doses for heavier cycles. For cycles including HCG during cycle — testes are already in better condition entering PCT and recovery is typically faster and more complete.
During-cycle HCG at conservative doses (250-500IU every 3-4 days) is the preferred approach for cycles of 12+ weeks — it maintains Leydig cell activity throughout the suppressive period so PCT begins with functionally intact testes. The pre-PCT blast approach (1,000-2,000IU daily for 5-10 days before SERMs) is used after cycles where during-cycle HCG wasn't used, but carries higher risk of LH receptor desensitisation and estrogen spike. Excessive HCG doses or duration can paradoxically impair recovery — conservative dosing is key.
Clomid is a 50/50 mixture of two isomers: enclomiphene (trans-isomer, the active LH/FSH stimulator) and zuclomiphene (cis-isomer, which has partial estrogenic activity and is associated with mood disturbances and visual effects). Enclomiphene is the isolated active isomer — same or greater LH/FSH stimulation without the zuclomiphene-related side effects. For users who have experienced mood issues or visual disturbances with Clomid, Enclomiphene is the direct pharmacological improvement.
When fertility and spermatogenesis restoration is specifically required. HCG provides LH activity (driving Leydig cell testosterone production) but no FSH activity. FSH is required to stimulate Sertoli cells, which support sperm maturation in the seminiferous tubules. Without FSH, sperm production cannot be fully restored regardless of testosterone recovery. HMG 150IU contains 75IU LH + 75IU FSH — adding the FSH component that completes the spermatogenesis signal. For testosterone recovery alone, HCG is sufficient. For fertility restoration, HMG provides the complete gonadotropin coverage.
Standard PCT duration is 4-6 weeks. Heavier or longer cycles may require 6-8 weeks. The only reliable indicator of successful PCT completion is a blood panel — total testosterone, free testosterone, LH and FSH returning to pre-cycle baseline ranges confirms recovery. Subjective indicators (libido, energy, mood returning to normal) are helpful secondary signals but not sufficient on their own. Many users run PCT for the minimum time then test at 6-8 weeks post-PCT start — if values are not back to baseline, the protocol is extended.