Dragon Pharma — Sexual Health
4 sexual health products covering all three primary PDE5 inhibitors plus a dual-combination formula — all FDA-approved active compounds, independently third-party tested, available as oral tablets.
Sexual Health
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Dragon Pharma Sexual Health — PDE5 Inhibitors
Dragon Pharma's sexual health range covers the three clinically established PDE5 inhibitors — Sildenafil, Tadalafil and Vardenafil — plus a proprietary dual-combination formula. All four products contain FDA-approved active pharmaceutical compounds, are independently third-party tested for compound identity and dosage accuracy, and are available as oral tablets in 100-tablet packs.
How PDE5 Inhibitors Work
All three compounds share the same mechanism: inhibition of phosphodiesterase type 5 (PDE5), the enzyme that breaks down cyclic GMP (cGMP) in corpus cavernosum smooth muscle. Sexual arousal triggers nitric oxide (NO) release, which elevates cGMP and causes smooth muscle relaxation and penile blood inflow. PDE5 normally terminates this process by breaking down cGMP. PDE5 inhibitors prevent this breakdown — sustaining cGMP elevation and enhancing the erectile response to sexual stimulation. Critically: PDE5 inhibitors amplify the response to arousal; they do not produce erection in the absence of sexual stimulation.
Sildenafil — The Original PDE5 Inhibitor
Sildenafil (Viagra DP) 50mg — the first-in-class PDE5 inhibitor, FDA-approved 1998. Onset 30-60 minutes, duration 4-6 hours. Discovered serendipitously during angina trials when participants reported unexpected erections. PDE5 IC50 approximately 3.5-4 nM. High-fat meals significantly delay absorption — take on empty or light stomach. The reference compound against which all other PDE5 inhibitors are measured.
Tadalafil — Longest Duration
Tadalafil (Cialis DP) 20mg — PDE5 IC50 approximately 0.9 nM, onset 30-60 minutes, duration 24-36 hours. The longest-acting PDE5 inhibitor available, enabling spontaneous sexual activity throughout the following day from a single dose. No significant food interaction. Also used as daily low-dose protocol (2.5-5mg) for continuous PDE5 support. The compound of choice for on-cycle daily PDE5 management where spontaneity is valued.
Vardenafil — Fastest Onset and Highest PDE5 Affinity
Vardenafil (Levitra) 20mg — PDE5 IC50 approximately 0.7 nM — the highest PDE5 binding affinity of all three compounds. Onset 15-30 minutes (fastest), duration 4-6 hours. Lower PDE6 activity than Sildenafil (fewer visual side effects), minimal PDE11 activity (no back/muscle ache). The compound of choice for fastest reliable onset and for users who have not achieved adequate response to Sildenafil.
Cock Bombs — Dual PDE5 Combination
Cock Bombs 70mg — Sildenafil 50mg + Tadalafil 20mg in a single tablet. The pharmacokinetic rationale: Sildenafil's sharp concentration peak provides the immediate 30-60 minute onset; Tadalafil's gradual but 24-36 hour duration takes over as Sildenafil clears — one dose provides both immediate effect and extended next-day coverage. Additive PDE5 inhibition and additive vasodilation — new users should start with half a tablet. Absolute contraindication with nitrates applies to both components.
Critical Safety — Nitrate Contraindication
All four products in this category share an absolute contraindication: never use PDE5 inhibitors with nitrate medications of any form — glyceryl trinitrate (GTN/nitroglycerin), isosorbide mononitrate, isosorbide dinitrate, or recreational amyl nitrite/alkyl nitrites ("poppers"). The combined vasodilatory mechanism produces severe, potentially fatal hypotension. This is not a "use with caution" interaction — it is an absolute contraindication regardless of dose or timing. Vardenafil additionally has a QTc prolongation effect — avoid with Class IA and Class III antiarrhythmics.
Frequently Asked Questions
Choose based on use case. Sildenafil suits planned activity where timing is predictable — take 30-60 minutes beforehand on an empty stomach. Tadalafil suits spontaneous activity and on-cycle daily dosing — 24-36 hour duration from one dose, no food restrictions. Vardenafil suits users who want fastest onset (15-30 minutes) or have found Sildenafil insufficient — its higher PDE5 affinity (0.7 nM IC50 vs Sildenafil's 3.5-4 nM) provides meaningfully better response in some users. Cock Bombs suits occasions where both fast onset and next-day coverage are wanted from a single dose.
AAS-induced ED has multiple mechanisms. Low testosterone post-cycle — profoundly low T reduces penile NO synthase activity that PDE5 inhibitors depend on; PCT and testosterone recovery are the primary intervention. Elevated estrogen on cycle — blunts central arousal signals; AI management is the primary intervention. Elevated prolactin from 19-nor AAS (Trenbolone, Nandrolone) — suppresses libido and arousal centrally where PDE5i is minimally effective; cabergoline is the intervention. Vascular damage from dyslipidaemia — PDE5 inhibitors are effective here. PDE5 inhibitors address the vascular component; hormonal causes require hormonal management.
Yes — no significant pharmacokinetic interactions exist between PDE5 inhibitors and commonly used AAS. The main on-cycle consideration is blood pressure: AAS cycles involving aromatising compounds frequently elevate blood pressure from water retention; PDE5 inhibitors cause vasodilation and blood pressure reduction which may compound or partially offset cycle hypertension. At standard doses this is manageable for most users, but monitoring blood pressure is advisable particularly during high-dose aromatising cycles.
Cock Bombs delivers Sildenafil 50mg + Tadalafil 20mg — standard clinical doses of both — in a single pre-formulated tablet. Taking them separately achieves the same pharmacological result but requires managing two products. The combination is additive: both compounds inhibit the same PDE5 enzyme producing greater total PDE5 inhibition than either alone, and the combined vasodilatory effect is also additive. New PDE5 inhibitor users should start with half a Cock Bombs tablet to assess individual response to the combined effect.
No — PDE5 inhibitors have no interaction with androgen receptors, testosterone, LH, FSH or the HPG axis. They act exclusively on PDE5 in vascular smooth muscle tissue. No testosterone suppression occurs and no post-cycle therapy is required after use of any PDE5 inhibitor. They can be used at any phase of an AAS cycle or PCT without concern for hormonal interference.