Natural GLP-1 as a Global Treatment Option

Obesity is a growing global health crisis, with rising rates across all age groups contributing to increased early mortality from diseases like diabetes, cardiovascular problems, and cancer. The World Health Organization (WHO) estimates that over 1.9 billion adults are overweight, with 650 million of these classified as obese. This condition increases the risk of numerous health problems, placing a significant burden on healthcare systems worldwide.

While the most common treatments involve pharmaceuticals and surgical methods, their side effects often lead to life-threatening consequences. The medications typically prescribed include synthetic GLP-1 agonists, which help lower blood sugar levels and promote weight loss, but can come with a range of adverse effects. Bariatric surgery, while effective for significant weight loss, also carries risks, including complications like infection, hernias, and long-term digestive issues, as well as the need for ongoing lifestyle changes and monitoring.

GLP-1, or glucagon-like peptide-1, is a hormone produced in the body that plays a crucial role in regulating blood sugar, appetite, and digestion. It stimulates insulin secretion, slows gastric emptying, and promotes satiety. Researchers are exploring ways to harness the power of naturally produced GLP-1 to potentially offer a safer and more sustainable approach to managing obesity.

Synthetic GLP-1 agonists used in obesity treatment can have a range of side effects, which vary depending on the medication. Orlistat commonly causes gastrointestinal issues such as diarrhea, flatulence, and bloating, with more serious risks including liver damage and kidney stones. Phentermine may lead to dry mouth, insomnia, increased heart rate, and elevated blood pressure, with the potential for heart palpitations and dependency. Liraglutide often causes nausea, vomiting, and diarrhea, while serious side effects include pancreatitis, thyroid tumors, and kidney problems. The combination drug Naltrexone/Bupropion can cause nausea, headaches, and insomnia, and carries risks of seizures, increased blood pressure, and psychiatric effects like mood swings.