Exemestane — Aromasin by Dragon Pharma
Aromasin is Dragon Pharma's formulation of Exemestane at 25mg per tablet — a steroidal aromatase inhibitor that binds the aromatase enzyme irreversibly. Supplied in a 100-tablet pack, Aromasin offers an alternative mechanism to non-steroidal AIs like Arimidex for managing estrogen-related side effects during a cycle or PCT.
Also searched as: Exemestane 25mg, Aromasin tabs, AI for PCT, Aromasin Dragon Pharma.
What Is Exemestane (Aromasin)?
Exemestane is a steroidal aromatase inhibitor — structurally similar to androgens, it binds permanently to the aromatase enzyme, irreversibly inactivating it ("suicide inhibition"). This differs from non-steroidal AIs like Anastrozole, which bind reversibly and are displaced as drug levels fall. Because Exemestane permanently inactivates each enzyme molecule it binds, the body must synthesise new aromatase enzyme to restore activity, which some users find produces a different practical dosing pattern compared to reversible AIs.
Effects and Benefits
- Reduces circulating estrogen levels through irreversible aromatase inhibition
- Manages water retention and bloating from elevated estrogen on aromatising compounds
- Reduces gynecomastia risk during cycles with testosterone or other aromatising AAS
- Some users report a more favourable impact on lipid profile (cholesterol) compared to non-steroidal AIs, though individual response varies
- Its steroidal structure means it may have mild direct effects on the androgen receptor in addition to its aromatase inhibition, distinguishing it from purely non-steroidal AIs
Dosage and Administration
| Use Case | Typical Dose | Frequency |
|---|---|---|
| On-cycle, moderate aromatising doses | 12.5 mg (½ tab) | Every other day |
| On-cycle, higher aromatising doses | 25 mg (1 tab) | Every other day to daily |
| PCT support | 12.5–25 mg | 2–3 times per week, as needed |
Aromasin's 25mg tablet is commonly split in half for the lower doses many users find sufficient on-cycle. With a half-life of approximately 24 hours, daily or every-other-day dosing is typical. As with any AI, the correct dose depends on the aromatising load of the compounds being used — many users start conservatively and adjust based on symptoms or bloodwork (estradiol levels).
Side Effects
Aromasin's side effects relate primarily to estrogen suppression, similar to other AIs, with some differences attributed to its steroidal structure:
- Joint pain and stiffness from reduced estrogen — a class effect shared with other AIs
- Lipid profile impact — some users report Aromasin is comparatively less harsh on cholesterol than non-steroidal AIs, though this varies individually
- Reduced libido and mood disturbances if estrogen is suppressed too far ("crashed E2")
- Does not itself suppress testosterone production — Aromasin is not a substitute for Post Cycle Therapy SERMs, which work through a different mechanism
Aromasin vs Arimidex
Dragon Pharma offers two aromatase inhibitors with different mechanisms:
- Aromasin (Exemestane) — a steroidal AI that binds the aromatase enzyme irreversibly; some users prefer it during PCT and report a more favourable lipid impact
- Arimidex (Anastrozole) — a non-steroidal AI that binds reversibly, making small dose adjustments more forgiving due to its reversible action
Both effectively reduce estrogen. Some users alternate between the two or switch to Aromasin during PCT specifically, based on the theory that its irreversible mechanism and reported lipid profile may better support the post-cycle hormonal recovery environment, though Arimidex's reversibility makes fine-tuning on-cycle doses more straightforward for some.
When and How Aromasin Is Used in a Cycle
Aromasin is commonly paired with aromatising compounds:
- Cypionat 250, Enantat 250 or other testosterone esters — the primary aromatising compounds most users run an AI alongside
- Dianabol — a strongly aromatising oral often requiring AI from the start of the cycle
- Nolvadex or Clomid — some users include Aromasin alongside SERMs during PCT specifically
"Aromasin is formulated at 25mg per tablet, easily split for the lower doses many of our customers use for on-cycle and PCT estrogen management with this steroidal AI."
Storage and Handling
Store Aromasin at room temperature, away from direct sunlight and moisture. Keep the original packaging sealed until use to maintain tablet potency over the product's shelf life.
