AICAR 50mg Acadesine Vial by Dragon Pharma

What It Is

AICAR (5-Aminoimidazole-4-Carboxamide Ribonucleotide), marketed here as Acadesine 50mg by Dragon Pharma, is an AMP-activated protein kinase (AMPK) activator used in research settings for its metabolic, endurance-enhancing, and fat-oxidation properties. As a synthetic analog of adenosine monophosphate (AMP), it influences cellular energy balance and promotes favorable metabolic adaptations.

How It Works

AICAR primarily activates AMPK, the body's central energy sensor. Once AMPK is stimulated, the cell shifts toward increased energy production and enhanced fatty acid oxidation. This process suppresses anabolic pathways that consume ATP and increases catabolic pathways that generate ATP. In practical research models, this results in improved glucose uptake, enhanced mitochondrial activity, and higher metabolic efficiency. These mechanisms explain AICAR's popularity in endurance and weight-management studies.

Benefits

AICAR's metabolic effects provide several measurable advantages in experimental and performance-focused environments. These include improved fatty acid utilization, increased aerobic capacity, accelerated energy turnover, and enhanced endurance output. Some users also report better nutrient partitioning and improved recovery during caloric deficits. Although not an anabolic compound, AICAR is valued for its body-composition support and performance-sustaining effects.

Who It Is For

AICAR is commonly selected by researchers and performance-oriented individuals examining metabolic enhancement, fat-loss support, and endurance adaptation. It is particularly utilized in bodybuilding contexts during cutting phases, intense cardiovascular training blocks, or when preserving energy efficiency under reduced caloric intake is required.

How to Use

AICAR 50mg is typically administered via subcutaneous injection in research models. Usage frequency often ranges from daily to every other day, depending on study design and metabolic goals. The vial should be reconstituted according to standard laboratory handling protocols, kept under sterile conditions, and stored appropriately during use. Dose volumes are dependent on concentration after reconstitution and the researcher's specific methodology.

Stacking Suggestions

AICAR is commonly explored alongside compounds that influence mitochondrial activity or thermogenic pathways, such as GW501516 (Cardarine) or mild thyroid-related research agents. However, because AICAR significantly impacts cellular energy balance, care must be taken to avoid overstimulation of metabolic pathways. Stacking is optional and not required for AICAR to exhibit its primary effects.

Side Effects

Most observations indicate that AICAR is generally well tolerated. Potential side effects may include fatigue, hypoglycemia-like sensations, mild flushing, gastrointestinal discomfort, or reduced strength output due to AMPK's temporary suppression of anabolic pathways. Overuse may disrupt glucose regulation or lead to decreased training performance in strength-focused settings. Monitoring metabolic responses and adjusting exposure accordingly is recommended.

Post Cycle Therapy (PCT)

AICAR does not influence androgen receptors or suppress endogenous hormone production. Its mode of action is metabolic rather than hormonal. For this reason, traditional post cycle therapy (PCT) protocols used with anabolic steroids are not required following AICAR research use.

FAQ

What is AICAR used for?

AICAR is used in research for improving endurance, enhancing fat oxidation, and supporting metabolic efficiency through AMPK activation. It is often examined in models focused on body composition, energy regulation, and performance capacity.

Is AICAR safe?

AICAR is generally well tolerated in controlled research settings, though individual responses may vary. Possible observations include fatigue, low-energy sensations, or changes in blood glucose handling. Responsible dosing and careful monitoring are recommended.

How does AICAR promote weight loss?

AICAR promotes weight-loss support by activating AMPK, which increases fatty acid oxidation, improves glucose uptake, and shifts metabolism toward using stored energy more efficiently. This creates a physiological environment that can facilitate fat reduction when combined with appropriate nutrition and training.

Who is AICAR 50mg used in bodybuilding?

In bodybuilding, AICAR 50mg is typically explored during cutting phases or endurance-heavy training periods. It is favored by athletes who want to support fat loss, maintain training performance, and improve energy efficiency during calorie-restricted phases.

What is AICAR dosage for athletes?

Dosages for athletes vary depending on research objectives and protocol design. Common approaches involve daily or every-other-day administration after proper reconstitution of the 50mg vial, always following strict laboratory handling standards and conservative titration to assess individual response.