What does DAC stand for and why does it matter?

DAC stands for Drug Affinity Complex — a chemical modification that enables CJC-1295 to reversibly bind to albumin in the bloodstream. This albumin binding protects the peptide from enzymatic degradation, extending its half-life from approximately 30 minutes (without DAC) to roughly 6-8 days. The same albumin-binding principle is used in pharmaceutical drugs like semaglutide to extend peptide half-life.

What is "GH bleed" and is it better than pulsatile GH release?

GH bleed refers to the continuous, low-level GH elevation CJC-1295 DAC produces throughout the week, in contrast to the sharp discrete pulses of natural GH secretion or short-acting secretagogues. It offers practical advantages (consistent IGF-1, no meal timing requirements) but some research suggests sustained non-pulsatile GH may increase insulin resistance slightly more than pulsatile GH. Neither pattern is universally superior — it depends on the user's specific goals and lifestyle.

Do I need to inject CJC-1295 DAC on an empty stomach?

No — this is a key practical advantage over CJC-1295 no DAC and other short-acting secretagogues. Because CJC-1295 DAC works through sustained albumin-bound release rather than acute pulsatile stimulation, meal timing does not significantly affect its efficacy.

Can CJC-1295 DAC be combined with Ipamorelin?

Yes, but the protocol differs from the no-DAC version. CJC-1295 DAC is injected once weekly providing a persistent GHRH background, while Ipamorelin is injected separately 1-3× daily for acute GH pulses — a layered rather than simultaneous approach.

How many injections does a 5mg vial provide?

At 1mg per injection once weekly, a 5mg vial provides 5 weekly injections — approximately 5 weeks. At 2mg per injection, it provides 2-3 weeks. The vial longevity is comparable to the 10mg no-DAC blend when accounting for the different dosing frequencies.

Does CJC-1295 DAC require PCT?

No. CJC-1295 DAC does not affect testosterone, estrogen, LH, FSH or the HPG axis. It can be used during AAS cycles, during PCT, or independently without any impact on hormonal recovery or natural testosterone production.

CJC-1295 DAC 5mg — Long-Acting GHRH Peptide Vial USA

Name: CJC-1295 Dac by Dragon Pharma
Brand: Dragon Pharma
SKU: OFFER-3819
Price: 69.0 USD
Availability: InStock

CJC-1295 DAC by Dragon Pharma

CJC-1295 DAC is Dragon Pharma's formulation of the long-acting GHRH analogue CJC-1295 with Drug Affinity Complex (DAC) at 5mg per vial. The DAC modification extends the compound's half-life from approximately 30 minutes (without DAC) to roughly 6-8 days — transforming a short-acting peptide into a long-acting sustained-release compound requiring only once or twice weekly dosing.

Also searched as: CJC-1295 DAC 5mg, long-acting GHRH, CJC 1295 with DAC, CJC-1295 Dragon Pharma.

What Does DAC Mean — The Drug Affinity Complex Explained

DAC (Drug Affinity Complex) is a chemical modification added to the CJC-1295 peptide chain that enables it to reversibly bind to albumin — the most abundant protein in blood plasma. This albumin binding is the mechanism behind the dramatically extended half-life:

Without DAC: CJC-1295 is rapidly degraded by DPP-IV (dipeptidyl peptidase IV) enzyme in the bloodstream, resulting in a ~30-minute half-life
With DAC: the albumin binding protects the peptide from DPP-IV degradation — the molecule dissociates from albumin, acts on GHRH receptors, then re-binds albumin, cycling in and out of active form
The result is a ~6-8 day effective half-life from a single injection, with the compound gradually releasing from its albumin reservoir over the week
This albumin-binding mechanism is the same principle used in several pharmaceutical drugs (including semaglutide/Ozempic) to extend peptide half-life

GH Bleed — What It Is and Why It's Debated

CJC-1295 DAC's sustained action produces what's called a "GH bleed" — a continuous, low-level GH elevation maintained throughout the week rather than discrete pulses. This differs fundamentally from both natural GH secretion and the pulsatile pattern produced by CJC-1295 no DAC + Ipamorelin:

Natural GH pattern: 5-9 discrete pulses per day, largest during slow-wave sleep, near-zero between pulses
CJC-1295 no DAC + Ipamorelin pattern: amplified discrete pulses, closely mimicking natural pulsatility
CJC-1295 DAC pattern: sustained low-level elevation throughout the week with blunted pulse amplitude

The GH bleed pattern has practical advantages (convenience, consistent IGF-1 elevation) but also potential concerns: some research suggests sustained non-pulsatile GH elevation may increase insulin resistance more than pulsatile GH, and the loss of the natural pulsatile pattern is a consideration for users prioritising sleep quality and circadian alignment.

Effects and Benefits

Sustained GH and IGF-1 elevation throughout the week from a single injection
Minimal injection burden — once or twice weekly dosing
Consistent, predictable GH elevation without the timing demands of short-acting peptides
Body recomposition support through elevated GH and downstream IGF-1
No suppression of natural testosterone — does not require Post Cycle Therapy

Dosage and Administration

Protocol	Typical Dose	Frequency
Standard	1–2 mg	Once weekly
Twice weekly	1 mg	Twice weekly (e.g. Mon/Thu)

At 5mg per vial, a single vial provides 2-5 weekly injections depending on dose. Unlike short-acting peptides, CJC-1295 DAC does not require timing relative to meals — because of its sustained-release mechanism, the compound maintains active levels regardless of insulin fluctuations during the day. This is a practical convenience advantage over short-acting GHRH peptides that must be dosed fasted.

CJC-1295 DAC vs CJC-1295 no DAC + Ipamorelin

Dragon Pharma offers both versions of this compound family:

CJC-1295 DAC (standalone) — long-acting, once weekly, sustained GH elevation, no meal timing required
CJC-1295 no DAC + Ipamorelin (blend) — short-acting, 2-3× daily, pulsatile GH pattern, must dose fasted

Factor	CJC-1295 DAC	CJC-1295 no DAC + Ipamorelin
Injection frequency	Once weekly	2–3× daily
Meal timing required	No	Yes — fasted dosing
GH pattern	Sustained "bleed"	Sharp pulsatile bursts
Sleep quality benefit	Modest	More pronounced
IGF-1 consistency	Very consistent	Variable (dose-timing dependent)
Insulin resistance concern	Slightly higher (sustained GH)	Lower (pulsatile pattern)
Vial longevity	5mg = 2–5 weeks	10mg = 8–25 days depending on frequency

Combining CJC-1295 DAC with a GHRP

Despite the half-life difference, CJC-1295 DAC can still be combined with a GHRP like Ipamorelin for additive receptor synergy. The practical approach differs from the no-DAC version:

CJC-1295 DAC is injected once weekly — providing a persistent GHRH receptor background
Ipamorelin is injected separately 1-3× daily for acute GH pulses on top of that background
This combination produces persistent GHRH stimulation from DAC plus pulsatile ghrelin receptor stimulation from Ipamorelin — a layered rather than simultaneous approach

Reconstitution and Storage

Reconstitute with bacteriostatic water — add slowly along the vial wall and swirl gently. Store reconstituted vial refrigerated at 2-8°C for up to 28-30 days. Never freeze. Calculate reconstitution volume based on intended dose per injection.

"CJC-1295 DAC was formulated for customers who want sustained GH axis support without the daily dosing discipline that short-acting peptides require — the albumin-binding mechanism delivering consistent results from a single weekly injection."