CJC-1295 no DAC + Ipamorelin Blend by Dragon Pharma
This CJC-1295 no DAC / Ipamorelin blend combines two complementary GH secretagogues in a single 10mg vial — a modified GHRH analogue and a selective ghrelin receptor agonist working through different receptors to produce synergistic GH release. The "no DAC" designation is critical to understanding how this blend differs from CJC-1295 with DAC, and why its dosing protocol is fundamentally different.
Also searched as: CJC-1295 no DAC Ipamorelin blend, Mod GRF 1-29 Ipamorelin, CJC Ipa blend Dragon Pharma.
CJC-1295 no DAC vs CJC-1295 with DAC — The Critical Distinction
This is the most important and most frequently misunderstood aspect of CJC-1295 products, and a genuine information gap in most competitor content:
| Parameter | CJC-1295 no DAC (this blend) | CJC-1295 with DAC |
|---|---|---|
| Also known as | Modified GRF(1-29), Mod GRF | CJC-1295 DAC |
| Half-life | ~30 minutes | ~6–8 days |
| GH release pattern | Pulsatile — sharp, physiological pulse | Sustained "GH bleed" — continuous elevation |
| Dosing frequency | 2–3× daily, timed to meals and sleep | Once or twice weekly |
| Synergy with Ipamorelin | Excellent — matched short half-lives produce simultaneous sharp pulse | Different timing — DAC provides a continuous base rather than a pulse |
| Cortisol elevation | Minimal at physiological pulsatile doses | Some studies show cortisol elevation with sustained GH bleed |
The key insight: CJC-1295 no DAC and Ipamorelin are ideally paired together because they share similar short half-lives (~30 min and ~2 hours respectively), both produce GH release through distinct receptor pathways, and when injected simultaneously, their combined effect produces a sharp, synergistic GH pulse that more closely mimics the body's natural pulsatile GH secretion pattern. CJC-1295 with DAC's week-long half-life creates a different pharmacodynamic profile that does not pair as naturally with Ipamorelin's short-acting pulsatile mechanism.
Why GHRH + GHRP Synergy Produces More GH Than Either Alone
The two components work on fundamentally different receptor systems in the pituitary:
- CJC-1295 no DAC binds GHRH receptors (GHRHR) on pituitary somatotroph cells, stimulating GH synthesis and release through cAMP-mediated pathways
- Ipamorelin binds ghrelin receptors (GHS-R1a) on the same somatotroph cells, stimulating GH release through phospholipase C / IP3 pathways — a completely separate signalling cascade
- When both receptors are activated simultaneously, the two pathways interact in a supra-additive manner — the combined GH response is significantly greater than the sum of each compound used alone
- Research has demonstrated that GHRH + GHRP combinations produce 3-5× the GH output of either compound alone at equivalent doses
Effects and Benefits
- Synergistic GH release significantly greater than either peptide alone — estimated 3-5× increase over monotherapy
- Pulsatile GH pattern closely mimicking physiological nocturnal GH secretion
- Improved sleep quality — nocturnal GH pulses occur during slow-wave sleep; amplifying this pulse improves sleep depth
- Body recomposition support through elevated GH and downstream IGF-1
- No suppression of natural testosterone — does not require Post Cycle Therapy
- No cortisol or prolactin elevation — Ipamorelin's hallmark selectivity is preserved in the blend
Dosage and Administration
| Protocol | Dose | Timing |
|---|---|---|
| Once daily (most common) | 100–200 mcg each component | Before bed, 2+ hours after last meal |
| Twice daily | 100 mcg each component | Before bed + upon waking (fasted) |
| Three times daily | 100 mcg each component | Pre-bed, waking, post-workout (fasted) |
Because both components have short half-lives, they must be dosed more frequently than CJC-1295 with DAC — typically 2-3 times daily for maximum effect. The most important dose is pre-sleep on an empty stomach, which amplifies the largest natural GH pulse of the day. Insulin significantly blunts GH release — dosing within 2 hours of food reduces the GH response substantially. With 10mg total vial content, dosing at 200mcg per injection provides approximately 25 injections from a single vial at once-daily dosing, or ~8 injections at three-times-daily dosing.
CJC-1295 no DAC / Ipamorelin vs CJC-1295 DAC / Ipamorelin
Dragon Pharma offers two versions of the CJC + Ipamorelin combination:
- CJC-1295 no DAC + Ipamorelin (this blend) — short-acting, pulsatile, 2-3× daily dosing, most physiological pattern, best for nocturnal GH pulse amplification
- CJC-1295 DAC (standalone) — long-acting, once or twice weekly dosing, provides sustained GH elevation base rather than sharp pulses
Neither version is strictly superior — they serve different protocols. CJC-1295 no DAC + Ipamorelin is preferred for users prioritising sleep quality, pulsatile GH mimicry and daily dosing flexibility. CJC-1295 DAC suits users wanting once or twice weekly dosing with sustained elevation, often combined with a separate pulsatile GHRP.
Reconstitution and Storage
Reconstitute with bacteriostatic water — add slowly along the vial wall and swirl gently. Store reconstituted vial refrigerated at 2-8°C for up to 28-30 days. Never freeze. Calculate reconstitution volume based on intended dose per injection before adding bacteriostatic water.
"The CJC-1295 no DAC / Ipamorelin blend was formulated specifically for users who understand why the no-DAC version pairs better with Ipamorelin's short half-life — matching release kinetics to produce a true synergistic GH pulse rather than a sustained bleed."
Stacking and Related Compounds
- Dragontropin (HGH) for users combining direct exogenous GH with secretagogue amplification
- BPC-157 + TB-500 Blend for recovery support alongside GH axis optimisation
- Ipamorelin + Tesamorelin Blend for users prioritising visceral fat loss alongside GH pulse amplification
