- Manufacturer: Dragon Pharma
- Substance: Metastin
- Dosage: 10 mg
- Form:Injection
- Packing: vial
- Brand Name: Kisspeptin
Kisspeptin by Dragon Pharma contains 10 mg of pure Kisspeptin-10 (Metastin) — the most potent natural trigger of GnRH and downstream LH/FSH release ever discovered. This research peptide is the master upstream regulator of the entire HPTA, capable of rapidly restarting natural testosterone production even after heavy, prolonged suppression.
What It Is
Kisspeptin-10 is the biologically active fragment of the KISS1 gene product. First identified in 1996, it is now recognized as the single most powerful endogenous stimulator of gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. A single dose can increase LH by 300–600% within minutes.
How It Works
Kisspeptin binds to the GPR54 (KISS1R) receptor on GnRH neurons, causing massive pulsatile release of GnRH → pituitary LH/FSH surge → rapid Leydig cell testosterone synthesis and ovarian stimulation. Unlike HCG, it acts upstream of the pituitary, making it far more physiological and capable of restoring natural pulsatile secretion patterns.
Kisspeptin Benefits
- Ultra-Fast HPTA Restart: LH/FSH spikes within 30–60 minutes
- Superior to HCG for PCT: Restores natural pulsatile release instead of direct stimulation
- Overcomes Severe Suppression: Effective even after 2+ years of TRT or heavy cycles
- Fertility Restoration: Dramatically increases sperm count and motility
- Female Libido & Fertility: Proven trigger of ovulation and sexual arousal
Who It's For
Advanced users coming off long/heavy cycles, men on TRT wanting to regain fertility, individuals with secondary hypogonadism, or couples using it off-label for timed ovulation and libido enhancement. Not for beginners or casual use.
How to Use
Reconstitution: Add 2 ml bacteriostatic water → 5 mg/ml
PCT Protocol (men): 100–200 mcg (0.02–0.04 ml) subcutaneous once daily or EOD for 2–4 weeks
Fertility Boost: 200–500 mcg EOD until blood work normalizes
Female Ovulation Trigger: 200–400 mcg single injection 36h before desired ovulation
Best timing: Evening, 2–3 hours after last meal
Stacking Suggestions
- Ultimate PCT Stack: Kisspeptin + low-dose Clomid + HMG
- Fertility Protocol: Kisspeptin + FSH analogue
- TRT Bridge: Kisspeptin 100 mcg EOD while tapering exogenous testosterone
Side Effects
- Very mild — occasional flushing or warmth 10–20 min post-injection
- Transient headache at very high doses (>1000 mcg)
- No desensitization with proper dosing (unlike GnRH analogues)
Post Cycle Therapy (PCT)
Kisspeptin is the PCT — it directly restarts the natural axis. Can be used standalone or to supercharge traditional SERM protocols.
Frequently Asked Questions
How is Kisspeptin better than HCG for PCT?
It acts upstream at the hypothalamus, restoring natural pulsatile GnRH/LH release instead of bypassing it. Users report faster and more complete recovery.
How fast does testosterone rise after Kisspeptin injection?
LH begins rising within 15–30 minutes, peaks at 2–4 hours, and testosterone increases are measurable within 24 hours.
Can Kisspeptin be used while still on cycle?
Yes — many advanced users run low-dose Kisspeptin (100 mcg EOD) during the final 4–6 weeks to keep the axis primed and dramatically shorten recovery time.
Is Kisspeptin effective for women?
Extremely — a single 200–400 mcg injection reliably triggers ovulation and significantly increases libido within hours.
Will repeated use cause receptor desensitization?
No — unlike GnRH analogues, physiological dosing of Kisspeptin-10 does not downregulate GPR54 receptors.
